Massachusetts [US], September 16 (ANI):슬롯 머신 사이트 추천Researchers discovered promising results indicating that irisin-based medicines may aid in the treatment of Alzheimer's disease.

The study was published in the journal Neuron.

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Previously, the first 3D human cell culture models of Alzheimer's disease (AD) that displayed the disease's two primary symptoms슬롯사이트”the production of amyloid beta deposits followed by tau tangles슬롯사이트”were produced. The model is currently being used by researchers to see if the exercise-induced muscle hormone irisin impacts amyloid beta pathology.

Physical activity has been shown in various AD animal models to reduce amyloid beta formation, while the underlying mechanisms remain unknown.

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Exercise enhances blood levels of irisin, a hormone produced by muscles that regulates lipid and glucose metabolism in fat tissue and increases energy expenditure by hastening the browning of white fat tissue.

Irisin has been found in human and mouse brains, and its levels are lowered in Alzheimer's patients and mouse models of the disease.

Se Hoon Choi, PhD, and Eun Hee Kim, PhD, of the MGH Genetics and Ageing Research Unit, together with other research colleagues, used irisin to assess if it plays a causal role in the link between exercise and lower amyloid beta.

슬롯사이트œFirst, we found that irisin treatment led to a remarkable reduction of amyloid beta pathology,슬롯사이트� said Choi. 슬롯사이트œSecond, we showed this effect of irisin was attributable to increased neprilysin activity owing to increased levels of neprilysin secreted from cells in the brain called슬롯 머신 사이트 추천astrocytes.슬롯사이트�

Neprilysin is an amyloid beta슬롯사이트“degrading enzyme that has been found to be elevated in the brains of mice with AD that were exposed to exercise or other conditions leading to reduced amyloid beta.The researchers uncovered even more details about the mechanisms behind irisin슬롯사이트™s link to reduced amyloid beta levels. For example, they identified integrin αV/β5 as the receptor that irisin binds to on astrocytes to trigger the cells to increase neprilysin levels.

Furthermore, they discovered that irisin슬롯사이트™s binding to this receptor causes reduced signalling of pathways involving two key proteins: extracellular signal-regulated kinase (ERK) and signal activator of transcription 3 (STAT3). Reduced ERK-STAT3 signalling was critical for the irisin-induced enhancement of neprilysin.

Previous studies have shown that in mice, irisin injected into the bloodstream can make its way into the brain, making it potentially useful as a therapeutic.

슬롯사이트œOur findings indicate that irisin is a major mediator of exercise-induced increases in neprilysin levels leading to reduced amyloid beta burden, suggesting a new target pathway for therapies aimed at the prevention and treatment of Alzheimer슬롯사이트™s disease,슬롯사이트� said 슬롯 머신 사이트 추천Rudolph Tanzi, PhD, a senior author of the study and director of the Genetics and Aging Research Unit. (ANI)

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